Dear Valued Shareholder,

This is [agent] with Alliance Advisors, on behalf of your Janus Detroit Street Trust.

Janus Henderson has announced a proposed transaction with Trian and General Catalyst.

At the meeting, shareholders are being asked to approve a new investment advisory agreement to allow Janus Henderson to continue managing your fund following the transaction.

You may submit your vote online or call 1-855-206-2309 for assistance.

[Individual Link here]

To review the meeting proposal, please click the following link:

https://www.sec.gov/Archives/edgar/data/1500604/000119312526085616/d24816ddef14a.htm

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